A case with sarcomatoid hepatocellular carcinoma.
10.3349/ymj.1998.39.4.390
- Author:
Jae Ho HAN
1
;
Young Nyun PARK
;
Woo Hee JUNG
;
Hoon Sang CHI
;
Chanil PARK
Author Information
1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. pathology@yumc.yonsei.ac.kr
- Publication Type:Case Reports
- Keywords:
Hepatocellular carcinoma;
sarcomatoid;
liver
- MeSH:
Carcinoma/pathology*;
Carcinoma/pathology*;
Carcinoma, Hepatocellular/pathology*;
Case Report;
Human;
Liver Neoplasms/pathology*;
Male;
Middle Age
- From:Yonsei Medical Journal
1998;39(4):390-394
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hepatocellular carcinoma (HCC) with sarcomatous features is a rare neoplasm which has been found in only 1.8% of surgically resected HCC and has a higher incidence of metastasis than usual HCC. We recently experienced a case of sarcomatoid HCC removed from a 49-year-old man. A surgically resected liver revealed a well-defined grayish-white solid firm mass showing extensive central necrosis and infiltrative growth margin. Microscopically, the entire tumor was composed of pleomorphic spindle cells with prominent nucleoli and frequent mitosis. It showed a sinusoidal infiltrative growth pattern at the tumor-nontumor boundary. The tumor cells reacted positively with AE3 (high molecular cytokeratin) and Vimentin and reacted negatively with AE1 (low molecular cytokeratin), cytokeratin19, carcinoembryonic antigen, alpha-fetoprotein, Factor VIII, CD31 and CD68. The spindle-shaped tumor cells were considered to originate from hepatocyte rather than from bile duct epithelium or mesenchymal elements.
