Optimal sedative dose of propofol to start MRI in children with cerebral palsy.
10.4097/kjae.2011.61.3.216
- Author:
Eun Jung KIM
1
;
Youn Yi JO
;
Hae Keum KIL
Author Information
1. Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Cerebral palsy;
MRI;
Propofol
- MeSH:
Aged;
Brain;
Cerebral Palsy;
Child;
Chin;
Humans;
Magnetic Resonance Imaging;
Michigan;
Neck;
Propofol
- From:Korean Journal of Anesthesiology
2011;61(3):216-219
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study was designed to determine the optimal sedative dose of propofol to start brain magnetic resonance imaging (MRI) in children with cerebral palsy (CP). METHODS: Twenty children, aged 0.5-5 years, were administered propofol to achieve a University of Michigan Sedation Scale (UMSS) score > or = 3 in the MRI room. The proper dose of propofol was determined using the up-and-down method. RESULTS: The ED50 and ED95 for successful sedation with a UMSS > or = 3 were 2.07 mg/kg (95% CI 1.69-2.56) and 2.69 mg/kg (95% CI 2.35-5.59). Respiratory events occurred in 5 patients and were resolved with neck extension, chin lift, or transient respiratory assistance with successful sedation. CONCLUSIONS: Low dose propofol can safely facilitate the initiation of MRI in children with CP.
