Clinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of Korean Patients.
10.3341/kjo.2015.29.5.285
- Author:
Hokyung CHOUNG
1
;
Young A KIM
;
Namju KIM
;
Min Joung LEE
;
Sang In KHWARG
Author Information
1. Department of Ophthalmology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
IGH-MALT1 fusion protein, human;
Lymphoma, B cell, marginal zone;
Translocation, genetic;
Trisomy
- MeSH:
Adult;
Aged;
*Chromosome Aberrations;
*Chromosomes, Human, Pair 14;
Chromosomes, Human, Pair 18/*genetics;
Eye Neoplasms/diagnosis/epidemiology/*genetics;
Female;
Humans;
In Situ Hybridization, Fluorescence;
Incidence;
Lymphoma, B-Cell, Marginal Zone/diagnosis/epidemiology/*genetics;
Male;
Middle Aged;
Republic of Korea/epidemiology;
Translocation, Genetic;
Young Adult
- From:Korean Journal of Ophthalmology
2015;29(5):285-293
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The incidence and clinical correlation of MALT1 translocation and chromosomal numerical aberrations in Korean patients with ocular adnexal mucosa associated lymphoid tissue (MALT) lymphoma have not yet been reported. We investigated the incidence and clinicopathologic relationship of these chromosomal aberrations in ocular adnexal MALT lymphomas in a Korean population. METHODS: Thirty ocular adnexal MALT lymphomas were investigated for the t(11;18) API2-MALT1, t(14;18) IgH-MALT1 translocations and chromosomes 3 and 18 aneuploidies using fluorescence in situ hybridization. Patient medical records were reviewed retrospectively for information on demographics and clinical characteristics, including treatment response. RESULTS: The MALT1 gene rearrangement was found in one out of 30 cases. The t(14;18) IgH-MALT1 translocation was demonstrated in only one case (3.3%), and the t(11;18) API2-MALT1 translocation was not found in any of the cases. Trisomy 3 was observed in three ocular adnexal MALT lymphomas (10.0%), and five cases showed trisomy 18 (16.7%). Translocation positive cases also showed trisomy 18. One case of tumor relapse showed trisomy 18 only in the recurrent biopsies. There were no statistically significant correlations between chromosomal aberrations and clinical characteristics and treatment responses. CONCLUSIONS: Translocations involving the MALT1 gene are not common in Korean ocular adnexal MALT lymphomas. The t(14;18) translocation was detected in only one out of 30 cases, and the t(11;18) translocation was not found at all. Furthermore, the chromosomal aberrations found in this study had no prognostic implications.
