Factors Affecting Treatment Outcome of Graft Infection Following Penetrating Keratoplasty.
10.3341/kjo.2015.29.5.301
- Author:
Mi Sun SUNG
1
;
Won CHOI
;
In Cheon YOU
;
Kyung Chul YOON
Author Information
1. Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea. kcyoon@jnu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Graft infection;
Penetrating keratoplasty;
Prognostic factor;
Treatment outcome
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Eye Infections, Bacterial/diagnosis/*etiology;
Eye Infections, Fungal/diagnosis/*etiology;
Female;
*Graft Survival;
Humans;
Keratoplasty, Penetrating/*adverse effects;
Male;
Middle Aged;
Prognosis;
Retrospective Studies;
Risk Factors;
Surgical Wound Infection/diagnosis/*etiology;
Treatment Outcome
- From:Korean Journal of Ophthalmology
2015;29(5):301-308
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the factors affecting treatment outcome of graft infection following penetrating keratoplasty (PKP). METHODS: In this retrospective study, 28 patients who underwent PKP between January 2005 and January 2013 and who were diagnosed with graft infection were classified into a treatment success group or a treatment failure group. Demographic and clinical characteristics, as well as the results of the microbiologic investigation, were analyzed and compared. A subsequent binary logistic regression analysis was performed to identify the prognostic factors affecting treatment outcome. RESULTS: Graft infection occurred at a mean of 38.29 +/- 36.16 months (range, 1 to 96 months) after PKP. Seventeen patients developed bacterial keratitis, and 11 patients developed fungal keratitis. Overall, of the 28 patients, nine (32.1%) were classified in the treatment failure group. Multivariate analysis identified pre-existing graft failure (p = 0.019), interval longer than 72 hours between donor death and PKP (p = 0.010), and fungal infection (p = 0.026) as significant risk factors for treatment failure. CONCLUSIONS: Pre-existing graft failure, extended interval between donor death and PKP, and fungal infection were important risk factors for treatment failure of graft infection following PKP.
