Sterile Inflammation after Intravitreal Injection of Aflibercept in a Korean Population.
10.3341/kjo.2015.29.5.325
- Author:
Ju Young KIM
1
;
Yong Sung YOU
;
Oh Woong KWON
;
Soon Hyun KIM
Author Information
1. Nune Eye Hospital, Seoul, Korea. kim1441@gmail.com
- Publication Type:Original Article
- Keywords:
Aflibercept;
Intravitreal injections;
Sterile inflammation
- MeSH:
Aged;
Aged, 80 and over;
Female;
Follow-Up Studies;
Humans;
Incidence;
Intravitreal Injections;
Macular Edema/*drug therapy/epidemiology;
Male;
Middle Aged;
Receptors, Vascular Endothelial Growth Factor/*administration & dosage;
Recombinant Fusion Proteins/*administration & dosage;
Republic of Korea/epidemiology;
Retrospective Studies;
Treatment Outcome;
Vascular Endothelial Growth Factor A;
Visual Acuity
- From:Korean Journal of Ophthalmology
2015;29(5):325-330
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To report the frequency and clinical features of sterile inflammation after intravitreal aflibercept injection in a Korean population. METHODS: A single-center, retrospective study was performed in patients who received intravitreal aflibercept from July 2013 through January 2015. RESULTS: A total of four cases of post-injection sterile inflammation were identified from 723 aflibercept injections in 233 patients. Patients presented 1 to 13 days after intravitreal aflibercept injection (mean, 5 days). The mean baseline visual acuity was 20 / 60, which decreased to 20 / 112 at diagnosis but ultimately recovered to 20 / 60. Three cases had inflammatory cells in the anterior chamber (mean, 2.25+; range, 0 to 4+), and all cases had vitritis (mean, 3+; range, 2+ to 4+). No patients had pain. Only one patient underwent anterior chamber sampling (culture negative) and injection of antibiotics. Three of four patients were treated with a topical steroid, and all experienced improvement in their symptoms and signs of inflammation. CONCLUSIONS: The overall incidence of sterile inflammation after intravitreal aflibercept injection in a Korean population was 4 of 723 injections (0.55%), or 4 of 233 patients (1.79%). Sterile inflammation after intravitreal aflibercept injection typically presents without pain, and the visual outcomes are generally favorable.
