A Case of Bone Marrow Necrosis Preceeding Acute Monoblastic Leukemia.
- Author:
Gyu Young JEONG
1
;
Hye Ryoung YOON
;
Sun Hee KIM
Author Information
1. Department of Clinical Pathology, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Bone marrow necrosis;
acute monoblastic leukemia (FAB, AML, M5a)
- MeSH:
Anemia;
Autopsy;
Bone Marrow*;
Follow-Up Studies;
Hematologic Neoplasms;
Hematopoiesis;
Humans;
Induction Chemotherapy;
Leukemia;
Leukemia, Monocytic, Acute*;
Leukopenia;
Low Back Pain;
Middle Aged;
Necrosis*;
Pancytopenia;
Prognosis;
Sepsis
- From:Korean Journal of Clinical Pathology
1999;19(2):172-176
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Bone marrow necrosis is rarely diagnosed during life but is more often seen at autopsy by accident. The prognosis of patients with bone marrow necrosis secondary to neoplastic disease is extremely poor. We experienced a 59-year-old man with acute monoblastic leukemia who developed bone marrow necrosis preceding leukemia. He's main complaint was continuous lower back pain. First hematologic examination showed anemia with leukopenia and extensive bone marrow necrosis. After suffering from sepsis and only supportive management, he spontaneously recovered from pancytopenia and achieved hypercellular marrow with trilineage hematopoiesis. After 6 months, he was diagnosed as acute monoblastic leukemia (FAB, AML, M5a) from the sudden appearence of leukemic blasts on peripheral blood smears. After induction chemotherapy, complete remission was achieved. Our experience suggests that bone marrow necrosis is not uncommonly associated with hematologic malignancy and occult cancer. When bone marrow necrosis is found, we should do close follow-up to find out underlying hidden malignancy.
