Expression of cytokeratin 10, 16 and 17 as biomarkers differentiating odontogenic keratocysts from dentigerous cysts.
10.5125/jkaoms.2012.38.2.78
- Author:
Jung Min KIM
1
;
So Young CHOI
;
Chin Soo KIM
Author Information
1. Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, Korea. kimcs@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Cytokeratin 10, 16, and 17;
Odontogenic keratocyst;
Dentigerous cyst
- MeSH:
Biomarkers;
Dentigerous Cyst;
Diagnosis, Differential;
Imines;
Keratins;
Odontogenic Cysts;
Thiazines
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2012;38(2):78-84
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: Odontogenic keratocysts (OKCs) have a tendency to recur and possess an aggressive nature. the aim of the present study was to evaluate cytokeratin (CK) expression patterns as a method for the differentiation between dentigerous cysts (DCs) and OKCs, as their histomorphologic appearance are often indistinguishable. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissue sections of 43 OKCs and 38 DCs were immunohistochemically analyzed with i-solution in a quantitative manner in order to evaluate the immunoreactivity of CK 10, 16 and 17. RESULTS: CK 10 expression was evident in 79.1% of OKCs but found in only 18.4% of DCs (P<0.05), and CK 10 expression was observed to occur more frequently in OKCs (mean 25.45%) than in DCs (2.19%) (P<0.05). The expression of CK 16 was evident in 79.1% of OKCs but found in only 7.9% of the DCs (P<0.05) and CK 16 expression was observed to occur more frequently in OKCs (mean 4.33%) than in the DCs (0.61%) (P<0.05). The expression of CK 17 was evident in 88.4% of OKCs but seen in only 15.7% of the DCs (P<0.05) and CK 17 expression was observed to occur more frequently in OKCs (mean 31.11%) than in the DCs (2.37%) (P<0.05). CONCLUSION: The immunohistochemical detection of CK 10, 16 and 17 can be utilized as a valuable biomarker for use in distinguishing between OKCs and DCs, which have clinically significant differential diagnoses.
