Genetic aberrations on the short arm of chromosome 8 (8p) in tongue carcinomas.
10.5125/jkaoms.2012.38.2.121
- Author:
Akiyuki MURANO
1
;
Kanae ONO
;
Hirofumi KOIKE
;
Yosuke ENDO
;
Ken SHIMADA
;
Kenshi KAWASAKI
;
Hitomi NOMURA
;
Masashi SHIIBA
;
Katsuhiro UZAWA
;
Hideki TANZAWA
Author Information
1. Department of Dentistry and Oral Surgery, Chiba University Hospital, Chiba, Japan. murano-cib@umin.ac.jp
- Publication Type:Review
- Keywords:
Loss of heterozygosity;
Tongue carcinoma;
FEZ1 gene;
Cathepsin B gene
- MeSH:
Arm;
Carcinoma, Squamous Cell;
Cathepsin B;
Chromosomes, Human, Pair 8;
Down-Regulation;
Humans;
Loss of Heterozygosity;
Microsatellite Repeats;
Tongue
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2012;38(2):121-126
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Aberrations on the short arm of chromosome 8 (8p) are frequently observed in several human cancers. In this study, 20 squamous cell carcinoma (SCC) specimens from the tongue were examined in order to evaluate the role of 8p in SCC of the tongue. Microsatellite analysis using 14 markers demonstrated two commonly deleted regions (CDRs) on 8p. Reverse transcription-polymerase chain reaction (RT-PCR) revealed frequent down-regulation of the FEZ1 gene, mapped to 8p22, and frequent over-expression of the cathepsin B gene, mapped to 8p-21-22. These results suggested that genetic aberrations are involved in the development of SCC of the tongue. However, no significant relationship was observed to be established between the genetic alterations and clinicopathological features. Thus, further investigation is necessary in order to clarify the clinical role of 8p in carcinoma of the tongue.
