Distribution of Coronary Artery Calcification in an Asymptomatic Korean Population: Association with Risk Factors of Cardiovascular Disease and Metabolic Syndrome.
- Author:
Donghee KIM
1
;
Su Yeon CHOI
;
Eue Keun CHOI
;
Jung Won SUH
;
Whal LEE
;
Young Sun KIM
;
Dae Hyun YOON
;
Jin Wook CHUNG
;
Byung Hee OH
Author Information
- Publication Type:Original Article
- Keywords: Coronary arteries; Pathologic calcification; Risk factors; Metabolic syndrome X
- MeSH: Biomarkers; Calcinosis; Cardiovascular Diseases; Coronary Artery Disease; Coronary Vessels; Female; Humans; Hypertension; Male; Metabolic Syndrome X; Myocardial Ischemia; Obesity; Obesity, Abdominal; Odds Ratio; Prevalence; Risk Factors; Waist Circumference
- From:Korean Circulation Journal 2008;38(1):29-35
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND AND OBJECTIVES: Coronary artery calcification (CAC) has been used as surrogate marker for coronary atherosclerosis. We developed a set of age-and gender-stratified CAC distribution and risk factors for CAC in a population of asymptomatic Korean subjects. SUBJECTS AND METHODS: Between 2003 and 2007, 3,961 asymptomatic subjects without a history of ischemic heart disease (male 64%, mean age 56+/-10 years) were screened for CAC by the use of multi-detector computed tomography. RESULTS: The total CAC score was assigned to a percentile according to age and gender. The prevalence of CAC and mean CAC score increased with age [p<0.001 by analysis of variance (ANOVA)]. The prevalence of CAC (mean CAC score) was 36.2% (60.5+/-236.1) in males, and 17.0% (15.1+/-84.0) in females. The age-and sex-adjusted odds ratio for the presence of CAC for subjects with diabetes was 1.542 [95% confidence interval (CI) 1.252-1.899], for subjects with hypertension was 1.673 (95% CI 1.430-1.956), for subjects with metabolic syndrome was 1.727 (95% CI 1.461-2.042), and for subjects with abdominal obesity (abdominal obesity defined as a waist circumference > or =90 cm in males; > or =80 cm in females) was 1.445 (95% CI 1.222-1.709). CONCLUSION: This study reports the distribution of CAC score by age and gender. It will serve as a reference standard for the clinical interpretation of CAC results in the asymptomatic Korean population.
