Acute Renal Failure Complicated by Valaciclovir in a Patient with IgA Nephropathy.
- Author:
Jeong Seon KIM
1
;
Hye Won KIM
;
Jae Won LEE
;
Hye Min CHOI
;
Sang Won PARK
;
Young Mo LEE
;
Ji Eun LEE
;
Young Joo KWON
;
Heui Jung PYO
Author Information
1. Division of Nephrology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea. yjkwon@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Valaciclovir;
Kidney failure;
Acute
- MeSH:
Acute Kidney Injury;
Acyclovir;
Aged;
Creatinine;
Cytomegalovirus;
Female;
Glomerulonephritis, IGA;
Herpesvirus 3, Human;
Humans;
Immunoglobulin A;
Middle Aged;
Nephritis, Interstitial;
Organothiophosphorus Compounds;
Renal Insufficiency;
Respiratory Muscles;
Valine
- From:Korean Journal of Nephrology
2008;27(2):248-250
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Valaciclovir is L-valyl ester of acyclovir which has the antiviral effect against herpes zoster virus and Cytomegalovirus. Its adverse effects were reported as nephrotoxicity and neurotoxicity. Although the mechanism of nephrotoxicity of valaciclovir is indeterminate, several hypotheses such as obstructive uropathy and interstitial nephritis have been suggested. We experienced a 54-year-old female patient with IgA nephropathy who developed acute renal failure after taking valaciclovir. She did not develop either central neuropathy or respiratory muscle weakness. The serum creatinine was normalized after 6 days by withdrawal of valaciclovir and hydration. When we use valaciclovir in the elderly or patients with preexisting renal disease, we should monitor the renal function carefully.
