Expressions of CD44s Is Associated with the Expression of Cyclooxygenase-2 in Non-Small Cell Lung Cancers.
- Author:
Sung Jig LIM
1
;
Hyun Jung KIM
;
Jung Yeon KIM
;
Kyeongmee PARK
Author Information
1. Department of Pathology, School of Medicine, Inje University, Sanggye Paik Hospital, Seoul 139-707, Korea. sungjig@sanggyepaik.ac.kr
- Publication Type:Original Article
- Keywords:
Carcinoma, Non-small-cell lung;
Cyclooxygease-2;
Antigens, CD44
- MeSH:
Adenocarcinoma;
Antigens, CD44;
Apoptosis;
Carcinoma, Non-Small-Cell Lung;
Carcinoma, Squamous Cell;
Cyclooxygenase 2*;
Humans;
Immunohistochemistry;
Lung Neoplasms*;
Lung*;
Neoplasm Metastasis
- From:Korean Journal of Pathology
2006;40(1):17-23
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The overexpression of Cox-2 in tumors is important for tumor invasion, angiogenesis, resistance to apoptosis and the suppression of host immunity. Moreover, a tumor's CD44 expression plays an important role in tumor invasion and metastasis. We examined the expression of COX-2 and also CD44 and its variants as well as the biological implications and relationship between Cox-2 and the CD44 variants in non-small cell lung carcinoma. METHODS: The expressions of Cox-2 and also CD44s and its variants (CD44v3 and CD44v6) were examined by performing immunohistochemistry on 98 surgical specimens. RESULTS: The expressions of CD44s, CD44v3 and CD44v6 were significantly more frequent in squamous cell carcinoma specimens than in the adenocarcinoma (CD44s, p=0.033; CD44v3, p=0.007; CD44v6, p=0.022). The loss of CD44s and CD44v3 were significantly correlated with poor tumor differentiation (CD44s, p=0.03; CD44v3, p=0.011). Patients with Cox-2 positive-adenocarcinoma tumors had a significantly worse cumulative survival than did those adenocarcinoma patients without the Cox-2 (p=0.048). The expression of Cox-2 was significantly associated with the CD44s expression in non-small cell lung cancer, and especially in squamous cell carcinoma. CONCLUSIONS: These findings suggest that expression of CD44s is associated with the expression of Cox-2 in NSCLC, and especially squamous cell carcinoma.
