Primary NK-/T- Cell Lymphoma of the Esophagus: a Case Presentation and Literature Review.
- Author:
Tae Hyung KIM
1
;
Ho Sang RYU
;
Chang Ha KIM
;
Hocheol HONG
;
Jin Sung KOH
;
Hoon Jai CHUN
;
Chang Duck KIM
;
Insun KIM
Author Information
1. Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. kumcrhs@kumc.or.kr
- Publication Type:Case Report
- Keywords:
Extranodal NK-T-cell lymphoma;
Esophageal primary ulcer;
Complete response
- MeSH:
Biopsy;
Endoscopy, Digestive System;
Esophagus;
Gastrointestinal Tract;
Granzymes;
Humans;
Lymphoma;
Lymphoma, Extranodal NK-T-Cell;
Lymphoma, Non-Hodgkin;
Male;
Middle Aged;
Nasal Cavity;
Nasopharynx;
Prognosis;
Skin;
Ulcer
- From:Korean Journal of Gastrointestinal Endoscopy
2010;41(4):208-213
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Extranodal natural killer/T-cell lymphoma (ENKL) is an uncommon neoplasm, and it is a subtype of non-Hodgkin's lymphoma. It most commonly presents in the nasal cavity and nasopharynx. But only 10% of ENKL may present on the skin or the gastrointestinal tract and this has a poor prognosis. We report here on a case of CD56+ NK/T-cell lymphoma that limited to the esophagus. A 55-year-old male patient presented with epigastric soreness. Esophagogastroduodenoscopy (EGD) showed well demarcated, longitudinal ulcerative lesions with an irregular base and a discrete margin on the lower esophagus. We performed EGDs and endoscopic biopsies 2 times, but these were insufficient to make a diagnosis. The 3rd time, we finally took a big piece of tissue using endoscopic mucosal resection with a cap-fitted panendoscope (EMR-C). The biopsies showed surface ulceration and a heavy lymphoid infiltration and a positive pattern for CD3, CD56 and granzyme B. The pathologic diagnosis was NK/T-cell lymphoma. The patient was treated with concurrent chemoradiation followed by additional chemotherapy and he achieved a complete response.
