Antibiotics-associated Diarrhea and Other Gastrointestinal Abnormal Responses Regarding Helicobacter pylori Eradication.
10.4166/kjg.2010.56.4.229
- Author:
Soon Beom KWON
1
;
Kook Lae LEE
;
Joon Suk KIM
;
Jae Kyung LEE
;
Won KIM
;
Yong Jin JUNG
;
Ji Bong JEONG
;
Ji Won KIM
;
Byeong Gwan KIM
Author Information
1. Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul National University College of Medicine, Seoul, Korea. kllee@brm.co.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
H. pylori eradication therapy;
Antibiotics;
Adverse effects
- MeSH:
Abdominal Pain/chemically induced;
Adult;
Alcohol Drinking;
Anti-Bacterial Agents/*adverse effects/therapeutic use;
Diarrhea/*chemically induced;
Female;
Flatulence/chemically induced/etiology;
Gastrointestinal Diseases/*chemically induced;
Helicobacter Infections/*drug therapy;
*Helicobacter pylori;
Humans;
Male;
Middle Aged;
Young Adult
- From:The Korean Journal of Gastroenterology
2010;56(4):229-235
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Helicobacter pylori (H. pylori) is closely related with a wide range of gastrointestinal disease. One-week triple therapy is currently considered as the golden standard for the treatment of H. pylori infection. However, gastrointestinal abnormal responses are major pitfalls in such regimen. The aim of this study was to identify symptoms, frequency and severity of antibiotics-associated gastrointestinal abnormal responses during H. pylori eradication therapy. METHODS: Sixty-seven patients with H. pylori infection between September 2005 and March 2006 were included. After 1 week of H. pylori eradication triple therapy (rabeprazol 10 mg, clarithromycin 500 mg, amoxicillin 1 g bid), we evaluated gastrointestinal abnormal responses (diarrhea, bloating, constipation, abdominal pain, borborygmus, flatulence, stool frequency, belching, and nausea) and severities every week for 4 weeks. RESULTS: The incidence of diarrhea was the highest in week 1, which was 41.28% (n=28) and the lowest in week 4, which was 9.52% (n=6) and decreased from week 1 to week 4 with statistical significance (p<0.0001). The most common gastrointestinal abnormal responses were associated with flatulence in week 1 (n=21, 31.34%), week 2 (n=21, 33.33%) and abdominal distention in week 3 (n=16, 25.40%), week 4 (n=15, 23.81%). Most of gastrointestinal abnormal responses were mild, and the most common symptom with higher than moderate grade was abdominal pain (n=4, 40.00%) in week 1. Alcohol consumption and coexisting medical illness were not associated with diarrhea (p=0.0852, 0.9009 respectively). CONCLUSIONS: H. pylori eradication therapy is commonly associated with antibiotics-associated gastrointestinal abnormal responses, which may result in antibiotics intolerance and H. pylori eradication failure. Even though those symptoms are not so severe, we have to consider the gastrointestinal abnormal responses associated with H. pylori eradication, especially diarrhea.
