Artificial Retina Mimbrane Assembly Utilzing Intelligent Materials: Biocompatibility and Electorphysiologic Features.
- Author:
Si Yeol KIM
1
;
Jeong Ok LIM
;
Hyung Duk SUH
;
Jung Hoon LIM
;
Jeung Soo HUH
Author Information
1. Department of Ophthalmology, School of Medicine, Kyungpook National University.
- Publication Type:Original Article
- Keywords:
Artificial retina;
Bacteriorhodopsin;
Biocompatibility;
Electro-physiology;
polypyrrole
- MeSH:
Anterior Chamber;
Bacteriorhodopsins;
Membranes;
Membranes, Artificial;
Polymers;
Rabbits;
Retina*
- From:Journal of the Korean Ophthalmological Society
1999;40(3):750-756
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In recent studies there have been various attempts at replacing a damaged retina with an artificial one. This paper outlines the assembly of an artificial retina membrane by incorporating a photorective protein bacteriorhodopsin into an electrochemically syntheszed conducting polymer polypyrrole. An electrophysiologic test was conducted to evaluate the photoresponsiveness of the bacteriorhodopsin and rabbit eyes were used to examine the biocompatibility of the artificial retina. The electrophysiologic test analyzed both wave forms and amplitudes obtained by photostimulating the artificial retina membrane with various light intensites(0.2, 2, 20J). In the biocompatibility test, the artificial membrane was inserted into the anterior chambers(4 eyes) and vitreous cavities(8 eyes) of rabbits. The condition of the eyes was then observed for one month. At the end of the first moonth, the eyes were enucleated and a histological examination was carried out. The electrophysiologic study displayed negative reflection waves, which are characteristic in rhodpsin, and their amplitudes showed a correspondign increase with stronger light intensities. The results of the biocompatibility test demonstrated that inflammatory reactions were not prominent in either the anterior chambers or the vitreous cavities during the first month and the histological examinations revealed no specific findings. In conclusion, a membrane assembled utilizing an electroactive polymer and a phocial retina.
