The Acute Effect of Betaxolol and Difivefrin on Optic Nerve Head and Retinal Blood Flow in Normal Tension Glaucoma.
- Author:
Ho Kyum KIM
1
;
Kyoung Yul SEO
;
Chan Yun KIM
;
Young Jae HONG
Author Information
1. The Institute of Vision Research, Yonsei University College of Medicine.
- Publication Type:Original Article
- Keywords:
Betxolol;
Blood flow;
Dipivefrin;
Heidelberg retina flowme-ter;
Normal tension glaucoma
- MeSH:
Arteries;
Betaxolol*;
Blood Pressure;
Ciliary Body;
Heart Rate;
Humans;
Intraocular Pressure;
Low Tension Glaucoma*;
Microcirculation;
Ophthalmic Solutions;
Optic Disk*;
Optic Nerve*;
Retina;
Retinaldehyde*;
Timolol
- From:Journal of the Korean Ophthalmological Society
1999;40(3):784-790
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effect of betaxolol and dipivefrin on microcirculation of peripapil lary reina and optic disc in normal tension glaucoma was assessed. Betaxolol, selective beta-1 blocker, was known to improve the blood flow of retrobulbar arteries, and dipivefrin was known to decrease the flow of ciliary body. Total subjects were 29 normal tension glaucoma patients; 18 subjects with no previous IOP reducing eye drops during 4 weeks were assigned for betaxolol group, and 11 subjects with using timolol for dipivefrin group. The intraocular pressure was significantly reduced after instillation in betaxolol group(p<0.01), and in dipivefrin group(p<0.05). But systemic blood pressure and pulse rate were not changed after instillations in both groups. Blood flow, volume, velocity of optic disc and peripapillary retina of betaxolol group and dipivafrin group were not significantly changed. From the above results, we concluded that betaxolol and dipiverin with timolol did not influenced the microcirculation of peripapillary retina and opit disc.
