Primary mediastinal large B-cell lymphoma: a single-center experience in Korea.
- Author:
Heui June AHN
1
;
Dok Hyun YOON
;
Shin KIM
;
Kyoungmin LEE
;
Eun Hee KANG
;
Jooryung HUH
;
Chan Sik PARK
;
Cheolwon SUH
Author Information
- Publication Type:Original Article
- Keywords: Lymphoma; B cell; PMBL; Prognosis; Treatment
- MeSH: B-Lymphocytes*; Consensus; Female; Follow-Up Studies; Humans; Korea*; L-Lactate Dehydrogenase; Lymphoma; Lymphoma, B-Cell*; Lymphoma, Non-Hodgkin; Prevalence; Prognosis; Survival Rate
- From:Blood Research 2014;49(1):36-41
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Primary mediastinal large B-cell lymphoma (PMBL) is a distinct subtype of non-Hodgkin lymphoma, which has no consensus for its ideal treatment or prognosis. METHODS: We reviewed the clinicopathologic features and clinical outcomes of 25 PMBL cases diagnosed at a single institution between 1993 and 2009 and compared them with 588 cases of non-mediastinal, diffuse large B-cell lymphoma (DLBCL, control group) diagnosed during the same period. RESULTS: Thirteen (52.0%) PMBL patients had Ann Arbor stage III or IV disease, and 10 (40.0%) had B symptoms. Thirteen (52%) PMBL patients were classified as high-intermediate/high-risk according to the International Prognostic Index. There was a significant prevalence of young (median: 31 years; range, 15-78 years; P<0.001), female (68%; P=0.014) patients in the PMBL group compared to the control group (median: 56 years; range, 15-85 years; 43.2% female). Bulky disease and elevated levels of lactate dehydrogenase (LDH) were more frequent in the PMBL group (P<0.001 and P=0.003, respectively). Nineteen (76%) PBML patients achieved complete remission, and 18 were alive at the last follow-up (median: 43 months; range, 1-92 months). There was no difference in the 3-year, overall survival rate (72%, 95% confidence interval [CI]: 54.0-83.0 versus 70.1%, 95% CI, 109.0-126.0; P=0.686) between PMBL and control patients, respectively. CONCLUSION: Compared to patients with non-mediastinal DLBCL, Korean patients with PMBL are predominantly young women with bulky disease and high LDH levels but with no significant difference in survival.
