A case of oxaliplatin-induced immune-mediated thrombocytopenia.

Author: Seong Eun SUH ¹ ; Moon Ju JANG ; So Young CHONG ; Richard H ASTER ; Brian R CURTIS ; Doyeun OH
Author Information

1. Department of Internal Medicine, School of Medicine, CHA University, Seongnam, Korea. doh@cha.ac.kr
Publication Type:Case Report
Keywords: Oxaliplatin; Thrombocytopenia; Immune; Drug-dependent platelet antibody
MeSH: Adrenal Cortex Hormones; Antibodies; Blood Platelets; Colonic Neoplasms; Drug Therapy; Flow Cytometry; Humans; Immunoglobulin G; Immunoglobulins; Korea; Middle Aged; Platinum; Thrombocytopenia*
From:Blood Research 2014;49(1):61-64
CountryRepublic of Korea
Language:English
Abstract: Oxaliplatin is a platinum compound used in patients with gastrointestinal malignancies. It is known to evoke a drug-induced immune-mediated thrombocytopenia, which has not been reported in Korea. We describe a 53-year-old man who developed oxaliplatin-induced immune-mediated thrombocytopenia during chemotherapy for colon cancer. Oxaliplatin-dependent IgG platelet antibodies were detected in his serum on flow cytometry. He was treated with immunoglobulin and corticosteroids without any complications. Physicians should consider oxaliplatin-induced immune-mediated thrombocytopenia, when a sudden, isolated thrombocytopenia develops during chemotherapy with oxaliplatin.