Nuclear Medicine Methods of Rejection Diagnosis in Transplanted Rat Model.
- Author:
Won Sang CHUNG
1
;
Sang Heon KIM
;
Hyuck KIM
;
Young Hak KIM
;
Jung Ho KANG
;
Yun Young CHOI
;
Chul Beom LEE
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Hanyang University, Korea. drkkkkkkk@hanmail.net
- Publication Type:Original Article
- Keywords:
Heart transplantation;
Graft rejection;
Rejection;
Radionuclide imaging
- MeSH:
Animals;
Biopsy;
Diagnosis*;
Graft Rejection;
Heart;
Heart Transplantation;
Models, Animal*;
Nuclear Medicine*;
Radionuclide Imaging;
Rats*;
Sensitivity and Specificity;
Spine;
Technetium Tc 99m Pyrophosphate
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2003;36(6):379-383
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: An accurate diagnosis of the severity of the rejection after a heart transplantation relies on endomyocardial biopsy, but because of its invasiveness and the need for repeated examination makes it is an inappropriate monitoring method. Therefore, we have tried to find a monitoring method that is continuous and less invasive. MATERIAL AND METHOD: Heterotopic heart transplantation using Ono-Lindsey Method was done in 20 rats, and then 99mTc-Pyrophosphate (PYP) scan was done after a month. Uptake ratio of transplanted heart to vertebrae (H/V) was obtained to be compared with the biopsy result. RESULT: Rejection was defined when the H/V uptake ratio was higher than 0.09, and we compared the uptake ratio with the results of biopsy. The result was true positives was 3, true negatives 12, false negatives 2, andfalse positives 3. Therefore sensitivity was 60% and specificity was 80%, diagnostic value was 75%. CONCLUSION: 99mTc-Pyrophosphate (PYP) scan was a useful method for the evaluation of the heart transplantation rejection and it will be helpful for monitoring rejection as an non-invasive and simple method.
