A Case of Hypertrophic Osteoarthropathy Associated with Epithelioid Hemangioendothelioma.
10.3346/jkms.2004.19.3.484
- Author:
Jin Hyun KIM
1
;
Eun Bong LEE
;
Sunyoung KIM
;
Hyoun Woo KANG
;
Jung Won SUH
;
Won Jae YOON
;
Su Hwan KIM
;
Eun Ha KANG
;
Churl Hyun IM
;
Yeong Wook SONG
;
Hyo Suk LEE
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. leb7616@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Hemangioendothelioma, Epithelioid;
Osteoarthropathy, Secondary Hypertrophic;
Vascular Endothelial Growth Factor
- MeSH:
Adult;
Biopsy;
Blood Platelets/metabolism;
Endothelium/metabolism;
Femur/radiography;
Hemangioendothelioma, Epithelioid/*complications/*pathology;
Human;
Lung/pathology;
Lung Neoplasms/*complications/pathology;
Male;
Osteoarthropathy, Secondary Hypertrophic/*complications/*pathology;
Vascular Endothelial Growth Factor A/metabolism;
Vascular Neoplasms/*diagnosis/pathology
- From:Journal of Korean Medical Science
2004;19(3):484-486
- CountryRepublic of Korea
- Language:English
-
Abstract:
Epithelioid hemangioendothelioma is a rare vascular tumor, which occurs in the lung, liver, bone, and soft tissue. Hypertrophic osteoarthropathy is a syndrome characterized by subperiosteal new bone formation, joint effusion and clubbing, and may be associated with cyanotic heart disease, chronic pulmonary disease, liver disease, and other miscellaneous diseases. The activation of endothelium and platelets has been suggested to be involved in the development of hypertrophic osteoarthropathy. We report a rare case of hypertrophic osteoarthropathy, which developed in association with hepatic epithelioid hemangioendothelioma with pulmonary metastasis. We also discuss the role of vascular endothelial growth factor in its pathogenesis.
