Radiofrequency Ablation to Treat Loco-Regional Recurrence of Well-Differentiated Thyroid Carcinoma.
10.3348/kjr.2014.15.6.817
- Author:
Sun Jin LEE
1
;
So Lyung JUNG
;
Bum Soo KIM
;
Kook Jin AHN
;
Hyun Seok CHOI
;
Dong Jun LIM
;
Min Hee KIM
;
Ja Seong BAE
;
Min Sik KIM
;
Chan Kwon JUNG
;
Se Min CHONG
Author Information
1. Department of Radiology, Chung-Ang University Hospital, Seoul 156-755, Korea.
- Publication Type:Original Article
- Keywords:
Radiofrequency ablation;
Recurrent thyroid cancer;
Efficacy;
Thyroid;
Ultrasound
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Carcinoma/*pathology/surgery/ultrasonography;
Catheter Ablation;
Female;
Follow-Up Studies;
Humans;
Male;
Middle Aged;
Neoplasm Recurrence, Local;
Neoplasm Staging;
Thyroglobulin/blood;
Thyroid Neoplasms/*pathology/surgery/ultrasonography;
Tomography, X-Ray Computed
- From:Korean Journal of Radiology
2014;15(6):817-826
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the efficacy of radiofrequency ablation (RFA) in the treatment of loco-regional, recurrent, and well-differentiated thyroid carcinoma. MATERIALS AND METHODS: Thirty-five recurrent well-differentiated thyroid carcinomas (RTC) in 32 patients were treated with RFA, between March 2008 and October 2011. RTCs were detected by regular follow-up ultrasound and confirmed by biopsy. All patients had fewer than 3 RTCs in the neck and were at high surgical risk or refused to undergo repeated surgery. Average number of RFA sessions were 1.3 (range 1-3). Post-RFA biopsy and ultrasound were performed. The mean follow-up period was 30 months. Pre- and post-RFA serum thyroglobulin values were evaluated. RESULTS: Thirty-one patients with 33 RTCs were treated with RFA only, whereas 1 patient with 2 RTCs was treated with RFA followed by surgery. At the last follow-up ultrasound, 31 (94%) of the 33 RTCs treated with RFA alone completely disappeared and the remaining 2 (6%) RTCs showed decreased volume. The largest diameter and volume of the 33 RTCs were markedly decreased by 93.2% (from 8.1 +/- 3.4 mm to 0.6 +/- 1.8 mm, p < 0.001) and 96.4% (from 173.9 +/- 198.7 mm3 to 6.2 +/- 27.9 mm3, p < 0.001), respectively. Twenty of the 21 RTCs evaluated with post-RFA biopsies (95%) were negative for malignancy. One (5%) showed remaining tumor that was removed surgically. The serum thyroglobulin was decreased in 19 of 26 patients (73%). Voice change developed immediately after RFA in 6 patients (19%) and was spontaneously recovered in 5 patients (83%). CONCLUSION: Radiofrequency ablation can be effective in treating loco-regional, recurrent, and well-differentiated thyroid carcinoma in patients at high surgical risk.
