Pharmacokinetics of ofloxacin in Patients with Multidrug-Resistant Tuberculosis.
10.4046/trd.2002.52.2.128
- Author:
Seung Kyu PARK
1
;
Young Ran YOON
;
Woo Chul LEE
;
Hyung Min JUN
;
Ji Hong SHON
;
Kyoung Ah KIM
;
Ji Young PARK
;
Jae Gook SHIN
Author Information
1. Department of Chest Surgery, National Masan Tuberculosis Hospital, Korea.
- Publication Type:Original Article
- Keywords:
MDR-Tb;
Ofloxacin;
Pharmacokinetics;
BMI
- MeSH:
Aminosalicylic Acid;
Area Under Curve;
Chromatography, High Pressure Liquid;
Cycloserine;
Emaciation;
Fluoroquinolones;
Humans;
Kanamycin;
Ofloxacin*;
Pharmacokinetics*;
Prothionamide;
Streptomycin;
Tuberculosis, Multidrug-Resistant*
- From:Tuberculosis and Respiratory Diseases
2002;52(2):128-136
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: There are few studies that have reported on the pharmacokinetic(PK) disposition of fluoroquinolones in patients with multi-drug resistant tuberculosis(MDR-Tb), even though fluoroquinolones are frequentl y co-prescribed to those patients. In this study, the PK disposition of ofloxacin, a fluoroquinolone, was evaluated in patients with MDR-Tb. METHODS: Twenty patients with MDR-Tb were given 2nd line Tb drugs including ofloxacin (300mg twice a day), prothionamide, cycloserine, para-aminosalicylic acid, kanamycin, and streptomycin. The patients were grouped according to their body mass index(BMI) as an index of emaciation (group A: 18.5
