Effect of Pantethine in the Treatment of Hyperlipidemia.
10.4070/kcj.1982.12.2.225
- Author:
Kyung Pyo HONG
;
Chung Hoo KANG
;
Myoung Mook LEE
;
Young Bae PARK
;
Jungdon SEO
;
Young Woo LEE
- Publication Type:Original Article
- MeSH:
Cholesterol;
Humans;
Hyperlipidemias*;
Triglycerides
- From:Korean Circulation Journal
1982;12(2):225-229
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
After pantethine in doses of 540 mg per day was administered for 8 weeks in 20 patients with hyperlipidemia, the serum levels of total cholesterol, triglyceride and HDL-cholesterol were compared with the pretreatment level. The serum level of total cholesterol decreased to 240+/-52 mg%[mean+/-standard deviation] after 4 weeks and 223+/-41 mg% after 8 weeks from the pretreatment level of 293+/-38 mg%(p<0.01). The serum triglyceride level also decreased to 254+/-109 mg% after 4 weeks and 239+/-114 mg% after 8 weeks from the pretreatment level of 375+/-126 mg%(p<0.01). But, there was no significant change in the serum levels of HDL-cholesterol before and after treatment (56+/-27 mg% beforAfter pantethine in doses of 540 mg per day was administered for 8 weeks in 20 patients with hyperlipidemia, the serum levels of total cholesterol, triglyceride and HDL-cholesterol were compared with the pretreatment level. The serum level of total cholesterol decreased to 240+/-52 mg%[mean+/-standard deviation] after 4 weeks and 223+/-41 mg% after 8 weeks from the pretreatment level of 293+/-38 mg%(p<0.01). The serum triglyceride level also decreased to 254+/-109 mg% after 4 weeks and 239+/-114 mg% after 8 weeks from the pretreatment level of 375+/-126 mg%(p<0.01). But, there was no significant change in the serum levels of HDL-cholesterol before and after treatment (56+/-27 mg% before treatment, 56+/-18 mg% after 4 weeks and 59+/-22 mg% after 8 weeks). Pantethine was well tolerated in most patients.
