Intrauterine therapy for macrocystic congenital cystic adenomatoid malformation of the lung.
10.5468/ogs.2014.57.2.102
- Author:
Jin Young MIN
1
;
Hye Sung WON
;
Mi Young LEE
;
Hye Jin SUK
;
Jae Yoon SHIM
;
Pil Ryang LEE
;
Ahm KIM
Author Information
1. Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. hswon@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Congenital cystic adenomatoid malformation of lung;
Fetal therapies;
Prenatal diagnosis;
Sclerosing solutions
- MeSH:
Cystic Adenomatoid Malformation of Lung, Congenital*;
Decompression;
Diagnosis;
Fetal Therapies;
Fetus;
Gestational Age;
Humans;
Hydrops Fetalis;
Infant, Newborn;
Lung*;
Picibanil;
Prenatal Diagnosis;
Retrospective Studies;
Sclerosing Solutions
- From:Obstetrics & Gynecology Science
2014;57(2):102-108
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To report on our experiences with thoracoamniotic shunting and/or the injection of a sclerosing agent (OK-432) to treat fetuses diagnosed with macrocystic congenital cystic adenomatoid malformation (CCAM) of the lung. METHODS: A retrospective study was undertaken in six fetuses with macrocystic CCAM at our institute that had been confirmed by postnatal surgery between August 1999 and January 2012. RESULTS: Six fetuses that had been diagnosed with macrocystic CCAM were analyzed. The median gestational age at diagnosis was 23.5 weeks (range, 19.5-31.0 weeks), and at the time of primary treatment was 24.0 weeks (range, 20.5-31.0 weeks). The mean size of the largest cyst at the initial assessment was 42.5+/-15 mm. Four fetuses were associated with mediastinal shifting, and one also showed fetal hydrops. All fetuses underwent a shunting procedure within the cysts, one case among them was also treated with OK-432. After the completion of all procedures, the mean size of the largest cyst was all decreased (14.2+/-12 mm). The median gestational age at delivery was 38.0 weeks (range, 32.4-40.3 weeks). All of the newborns underwent the surgical resection at a median age of 6 days (range, 1-136 days) and are currently doing well without any complications. CONCLUSION: We suggest that intrauterine decompression therapy to manage fetal macrocystic CCAM is recommendable treatment for good perinatal outcome.
