Wegener's Granulomatosis Presenting as Pyoderma Gangrenosum.
- Author:
Jeong Eun KIM
1
;
Hyo Hyun AHN
;
Young Chul KYE
;
Soo Nam KIM
Author Information
1. Department of Dermatology, College of Medicine, Korea University, Seoul, Korea. dermp@shinbiro.com
- Publication Type:Case Report
- Keywords:
ANCA;
Pyoderma gangrenosum;
Wegener's granulomatosis
- MeSH:
Antibodies, Antineutrophil Cytoplasmic;
Biopsy;
Cyclophosphamide;
Female;
Humans;
Inflammation;
Leg;
Lung;
Middle Aged;
Pyoderma;
Pyoderma Gangrenosum;
Skin;
Ulcer;
Vasculitis;
Wegener Granulomatosis
- From:Korean Journal of Dermatology
2008;46(1):117-121
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Wegener's granulomatosis (WG) is a systemic disease of unknown origin characterized by necrotizing granulomatous inflammation and vasculitis. Dermatological symptoms occur in up to 50% of cases, mostly in the form of cutaneous vasculitis or pyoderma gangrenosum. A 51-year-old female presented with multiple ulcerative patches and erythematous nodules on both legs. Histopathological findings showed extensive ill-defined granulomatous lesions and necrotizing vasculitis. Lung biopsy findings were consistent with WG. Nasopharyngeal and gastrointestinal involvement developed later. Skin lesions are improving with systemic corticosteroid and cyclophosphamide. We herein report a case of WG presenting as pyoderma gangrenosum-like cutaneous manifestation with other systemic involvements.