Tumor Grading of Adult Astrocytic Glioma on MR Imaging.
10.3348/jkrs.1994.31.3.377
- Author:
Hong Sik BYUN
;
Dae Chul SUH
;
Kyu Ho CHOI
;
Moon Hee HAN
;
Choong Gon CHOI
;
Kee Hyun CHANG
;
Jung Ho SUH
;
Woo Suk CHOI
;
Seon Kyu LEE
;
Ho Kyu LEE
- Publication Type:Original Article
- MeSH:
Adult*;
Astrocytoma*;
Biopsy;
Edema;
Glioblastoma;
Hemorrhage;
Humans;
Magnetic Resonance Imaging*;
Necrosis;
Neoplasm Grading*;
Population Characteristics;
Retrospective Studies
- From:Journal of the Korean Radiological Society
1994;31(3):377-384
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study is to determine predictive MR features for grading of astrocytic gliomas and to evaluate the accuracy of MR grading in these tumors. MATERIALS AND METHODS: We retrospectively reviewed 135 cases of supratentorial astrocytic gliomas in adult (age > 15 years), all of which were proved by open biopsy. Two observers analysed MR images independently with criteria of margin, edema, mass effect, signal heterogeneity, necrcosis, cyst formation, hemorrhage, tumor vascularity, enhancement degree, and enhancement size. The patterns of enhancement were categorized into no, homogeneous, heterogeneous, thin smooth rim, thin irregular rim, and thick irregular rim enhancement patterns. Observers finally diagnosed each case as one of low-grade astrocytoma, anaplastic astrocytoma or glioblastoma multiforme. RESULTS: Statistically significant MR features for grading of these tumors were revealed as necrosis (p < 0. 001), edema (0.008), and signal heterogeneity (p < 0.025). When compared with histopathologic grading, MR graded correctly 76%-77% of cases in two tiered system(low-grade astrocytoma versus high-grade astrocytoma), but only 67%-69% of cases in three tiered system(low-grade astrocytoma, anaplastic astrocytoma, glioblastoma multiforme). No contrast enhancement was seen in 45% and 23% of low-grade astrocytoma and anaplastic astrocytoma respectively. Glioblastoma multiforme frequently showed thick irregular rim enhancement (57%), but no enhancement at all in 8%. CONCLUSION: We have concluded that necrosis and edema are significant predictive MR features for gradomg of supratentorial astrocytic gliomas in adult, and MR was correct in 76%--77% of cases for predicting pathologic grading of astrocytomas in two tiered system.
