Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues.
10.3346/jkms.2001.16.3.313
- Author:
Dong Sun KIM
1
;
Chang Beom LEE
;
Yong Soo PARK
;
You Hern AHN
;
Tae Wha KIM
;
Choon Suhk KEE
;
Ju Seop KANG
;
Ae Son OM
Author Information
1. Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea. dskim@hmc.hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Alcohol Dehydrogenase;
Thyroid Hormones;
Thyrotoxicosis
- MeSH:
Alcohol Dehydrogenase/*metabolism;
Animal;
Gastric Mucosa/enzymology;
Kidney/enzymology;
Liver/drug effects/*enzymology;
Lung/enzymology;
Male;
Rats;
Rats, Sprague-Dawley;
Stomach/drug effects/*enzymology;
Thyrotoxicosis/chemically induced/metabolism;
Thyroxine/administration & dosage/*metabolism/pharmacology
- From:Journal of Korean Medical Science
2001;16(3):313-316
- CountryRepublic of Korea
- Language:English
-
Abstract:
The effects of thyroid hormone on hepatic and gastric alcohol dehydrogenase (ADH) activities (nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats treated with thyroxine (1 mg/kg, po) for 14 days. Whereas hepatic ADH activity in thyroxine-treated rats decreased by 61.3% of control rats (26.4 vs 43.2, p<0.001), gastric ADH activity increased by 262.9% of control rats (4.9 vs 1.9, p<0.001). As for the activities of the lung and kidney, thyroxine treatment did not produce any statistically significant changes. These data suggest that thyrotoxicosis causes a decrease of hepatic alcohol metabolism, and that the increase of gastric ADH activity in thyrotoxic rats can partly restore the first-pass metabolism of ethanol.
