Systemic lupus erythematosus complicated with cerebral venous sinus thrombosis: a report of two cases.
10.3346/jkms.2001.16.3.351
- Author:
Myung Kwon LEE
1
;
Jae Han KIM
;
Hye Ryun KANG
;
Hyun Joo RHO
;
Eon Jeong NAM
;
Shin Woo KIM
;
Young Mo KANG
;
Jong Myung LEE
;
Nung Soo KIM
Author Information
1. Department of Internal Medicine, School of Medicine, Kyungpook National University, Taegu, Korea. jomlee@knu.ac.kr
- Publication Type:Case Report
- Keywords:
Systemic Lupus Erythematosus;
Sinus Thrombosis, Intracranial
- MeSH:
Adult;
Anti-Inflammatory Agents, Steroidal/therapeutic use;
Anticoagulants/therapeutic use;
Brain/radiography;
Cyclophosphamide/therapeutic use;
Female;
Glucocorticoids, Synthetic/therapeutic use;
Heparin/therapeutic use;
Human;
Immunosuppressive Agents/therapeutic use;
Lupus Erythematosus, Systemic/*complications;
Magnetic Resonance Imaging;
Methylprednisolone/therapeutic use;
Middle Age;
Sinus Thrombosis, Intracranial/*complications/drug therapy/physiopathology/radiography;
Treatment Outcome;
Warfarin/therapeutic use
- From:Journal of Korean Medical Science
2001;16(3):351-354
- CountryRepublic of Korea
- Language:English
-
Abstract:
A rare manifestation of systemic lupus erythematosus (SLE) is cerebral venous sinus thrombosis (CVST), in which early diagnosis and aggressive therapy are of prime importance for favorable outcome. The pathogenesis of CVST is largely unknown, but it is thought to be caused by cerebral vasculitis, antiphospholipid antibodies or other conditions associated with enhanced coagulability. We describe two cases of SLE with CVST which were not associated with antiphospholipid antibodies. Both cases were treated with immunosuppressants (intravenous methylprednisolone and cyclophosphamide pulse therapy) and anticoagulant drugs (heparin and subsequent maintenance therapy with warfarin). There was a marked improvement of neurologic symptoms with the disappearance of thrombus in a follow-up MRI. The possibility of CVST should be considered in any patients with SLE who show neuropsychiatric manifestations.
