MRI follow-up study and 1H-MR spectroscopic finding in a patient with Kearns-Sayre syndrome.
- Author:
Chulhee CHOI
1
;
Il Nam SUNWOO
;
Tae Seung KIM
;
Pyoung JEON
Author Information
1. Department of Neurology, College of Medicine Yonsei University.
- Publication Type:Original Article
- Keywords:
Kearns Sayre syndrome;
MR spectroscopy;
lactate
- MeSH:
Blepharoplasty;
Brain;
Brain Stem;
Cerebellum;
Cerebrum;
Female;
Follow-Up Studies*;
Humans;
Kearns-Sayre Syndrome*;
Lactic Acid;
Magnetic Resonance Imaging*;
Magnetic Resonance Spectroscopy;
Ophthalmoplegia, Chronic Progressive External;
Protons;
Thalamus
- From:Journal of the Korean Neurological Association
1998;16(3):388-391
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Serial Brain MRI was performed on a seventeen-year-old girl with Kearns-Sayre syndrome. At the age of 11, she complained bilateral ptosis. Two years later, bilateral blepharoplasty was done and brain MRI was taken. T2-weighted MRI sequence showed high signal intensity areas in the brainstem, thalamus and white matter of the cerebrum and cerebellum bilaterally. Four years later, chronic progressive external ophthalmoplegia developed and serial MRI and proton MRS were taken. Follow-up MRI showed similar but slightly progressed findings compared with previous films. The proton MR spectroscopic imaging demonstrated focal localization of abnormally increased lactate content in the involved area of the brain.
