The Effect of 5-FU(5-fluorouracil) in the Filtering Surgery.
- Author:
Jong Ho LEE
1
;
Hee Seong YOON
;
Sae Heun RHO
Author Information
1. Department of Ophthalmology, Dong-A University, College of Medicine Pusan, Korea.
- Publication Type:Original Article
- Keywords:
5-Fluorouracil;
risky glaucoma;
trabeculectomy
- MeSH:
Blister;
Cicatrix;
Fibroblasts;
Filtering Surgery*;
Fluorouracil;
Follow-Up Studies;
Glaucoma;
Glaucoma, Neovascular;
Humans;
Intraocular Pressure;
Trabeculectomy
- From:Journal of the Korean Ophthalmological Society
1993;34(10):1044-1049
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
An antimetabolite, 5-fluorouracil(5-FU) has a property of inhibiting fibroblast proliferahon and is known to increase success rate of glaucoma filtering surgery in patients at risk by preventing postoperative scarring of a filtering bleb. Thirteen eyes of 13 patients with uncontrolled glaucoma at high risk for failures of standard filteration underwent trabeculectomy with post-operative 5-FU subconjunctival injections. The mean follow-up time was 7.3 months. The intraocular pressure was controlled in 77% of the over-all study patients after 1 month, 69% after 2 months and 54% after 6months, respectively. In patients with neovascular glaucoma, the intraocular pressure was controlled in 80% of the patients after 1 month and 60% after 2 months and 40% after 6 months. A corneal epithelial defect was the most common complicatio. No other severe complications were observed.
