A Complex Chromosomal Rearrangement Involving 46,XX,t(1;7;16)(p32.1;q22;q13) in a Female with Recurrent Miscarriages After in vitro Fertilization.
- Author:
Hanjoon KIM
1
;
Juwon KIM
;
Young UH
;
Kap Jun YOON
;
Hyuck Dong HAN
Author Information
- Publication Type:In Vitro ; Case Report
- Keywords: Complex chromosomal rearrangement; Infertility; in vitro fertilization
- MeSH: Abortion, Habitual; Counseling; Cytogenetic Analysis; Cytogenetics; Female; Fertilization in Vitro; Humans; Infertility; Lifting; Mass Screening; Pregnancy; Pregnancy, Twin
- From:Laboratory Medicine Online 2013;3(3):178-182
- CountryRepublic of Korea
- Language:Korean
- Abstract: Balanced complex chromosomal rearrangements involving three or more chromosomes are often detected in phenotypically normal female patients with an adverse obstetric history. Here, we report a 32-yr-old phenotypically normal female with a history of multiple in vitro fertilization (IVF) failures and carrying a balanced complex chromosomal rearrangement involving chromosomes 1, 7, and 16. Cytogenetic analysis revealed the following complex karyotype: 46,XX,t(1;7;16)(p32.1;q22;q13). The patient achieved a twin pregnancy after IVF, although no heartbeat was detected during the sixth gestational week checkup. Tissues from intrauterine fetal demise were tested for chromosomal analysis and revealed 46,XX,t(1;7;16)(p32.1;q22;q13)mat and 46,XY,der(1)t(1;16)(p32.1;q13),der(7)t(1;7) (p32.1;q22)mat. This case illustrates the importance of chromosomal analysis in infertile females or infertile females with multiple IVF failures. Therefore, it would be beneficial for patients visiting infertility clinics to undergo cytogenetic screening for complex chromosome rearrangements before further counseling and prenatal investigations.
