Immunohistochemical Study on Expression of the p53 Protein in Medulloblastoma/PNET.
- Author:
Eun Jung KIM
1
;
Sang Soo PARK
;
Young Ho LEE
;
Ahn Hong CHOI
;
Seo Hee RHA
;
Soon Yong LEE
;
Hye Kyoung YOON
;
Young Tak LIM
;
Do Yoon PARK
;
Kang Suek SUH
Author Information
1. Department of Pediatrics, Dong-A University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Medulloblastoma;
Primitive neuroectodermal tumor;
Immunohistochemical stain;
p53
- MeSH:
Busan;
Humans;
Medulloblastoma;
Neoplasm Metastasis;
Neural Plate;
Neuroectodermal Tumors, Primitive;
Recurrence;
Retrospective Studies
- From:Journal of the Korean Cancer Association
1997;29(5):867-873
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The present study explores the expression rate of p53 mutation and the correlation between the expression of p53 protein and prognostic factors in medulloblastoma/ PNET (primitive neuroectodermal tumor). MATERIALS AND METHODS: We studied retrospectively 24 patients with medulloblastoma/ PNET, who were admitted in Dong-A University Hospital, Pusan National University Hospital and Inje University Pusan Paik Hospital from 1988 to 1995. Detection of p53 mutations was made by immunohistochemical staining of p53 protein on paraffin- embedded tissues. The correlation between the expression of p53 protein and prognostic factors was evaluated by the Spearman correlation analysis. RESULTS: p53 protein was expressed in 6 of 24 patients (25%). In 20 patients who could be evaluated for metastasis, 16 patients of M0, 1 patient of M1 and 3 patients of M2 were grouped by M stage, and the expression of p53 was detected in 1 of 16 M0 group (6.3%) and 3 of 3 M2 group (100%). p53 expression was significantly related to the M stage of medulloblastoma/PNET (r=0.73, p<0.001). The detection of p53 was not significantly associated with T stage, cellular differentiation and the relapse rate of medulloblastoma/ PNET. CONCLUSION: The immunohistochemical detection rate of p53 protein in medulloblastoma/ PNET was 25%. The expression of p53 protein was significantly related to the M stage, with higher expression rate in M2 group of medulloblsatoma/PNET.
