Perinatal Outcome in Preterm Infants with Abnormal Umbilical Artery Doppler Results : Emphasizing on Early Onset Thrombocytopenia and its Risk Factors.
- Author:
Kyoung Eun JOUNG
1
;
Seung Han SHIN
;
Jae Ri KIM
;
Eun Sun KIM
;
Sang Duk KIM
;
Do Hyeon KIM
;
So Yeon SHIM
;
Ee Kyung KIM
;
Han Suk KIM
;
Beyong Il KIM
;
Jung Hwan CHOI
Author Information
1. Departments of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea. kimek@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Umbilcal artery Doppler;
Placental insufficiency;
Preterm neonates;
Hematologic profile;
Nucleated red blood cell;
Platelet;
Early onset thrombocytopenia
- MeSH:
Arteries;
Blood Platelets;
Erythrocytes;
Gestational Age;
Humans;
Infant, Newborn;
Infant, Premature*;
Intensive Care, Neonatal;
Length of Stay;
Leukocytes;
Medical Records;
Mothers;
Parturition;
Placental Insufficiency;
Platelet Count;
Pregnancy;
Retrospective Studies;
Risk Factors*;
Seoul;
Thrombocytopenia*;
Umbilical Arteries*
- From:Journal of the Korean Society of Neonatology
2006;13(2):233-243
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE:Umbilical artery Doppler study is a commonly used non-invasive tool in high risk pregnancies because of its good correlation with the degree of placental insufficiency. We analyzed hematologic profiles and perinatal outcome of preterm infants with abnormal umbilical artery Doppler results and the risk factors of early onset thrombocytopenia. METHODS:We retrospectively reviewed the medical records of preterm infants under 35 weeks of gestational age at birth who were admitted to the neonatal intensive care unit of Seoul National University Children's Hospital from January 1, 2002 through December 31, 2004, and whose mothers had undergone umbilical artery Doppler studies within 5 days before delivery. Sixty two neonates were divided into three groups; the 1st group was defined as the patients with normal umbilical artery (UA) systolic/diastolic (S/D) ratio, the 2nd group, with increased UA S/D ratio above 95 percentile, and the 3rd, with absent or reversed end-diastolic flow (AREDF). RESULTS:Mean nucleated red blood cell (nRBC) counts per 100 white blood cells (WBCs) were 14.2 (0-150), 91.0 (0-262), 301.4 (6-884) (P<0.001), mean WBC counts were 10.8 (0- 34.1), 9.2(3.4-23.9), 5.9(0.5-15.2) (x1,000/mm(3)) (P=0.007), and mean platelet counts were 215.5+/-69.2, 185.9+/-96.7, 100.2+/-50.3 (x1,000/mL) (
