Changes in biochemical markers of bone turnover and bone mineral density during pregnancy and postpartum in korean women.
- Author:
Si Won LEE
1
;
Jae Hyug YANG
;
Dal Soo HONG
;
Moon Young KIM
;
Jin Hoon CHUNG
;
Ki Ok HAN
;
Dong Hee CHO
Author Information
1. Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea. jhy60408@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Pregnancy;
Postpartum;
Biochemical markers of bone turnover;
Bone mineral density
- MeSH:
Absorptiometry, Photon;
Alkaline Phosphatase;
Biomarkers;
Bone Density;
Bone Resorption;
Calcium;
Female;
Humans;
Osteocalcin;
Osteogenesis;
Parathyroid Hormone;
Phosphorus;
Postpartum Period;
Pregnancy;
Pregnancy Trimester, Second;
Pregnancy Trimester, Third;
Pregnant Women;
Prospective Studies
- From:Korean Journal of Obstetrics and Gynecology
2009;52(2):166-179
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To show the patterns of changes in biochemical markers of bone turnover and ultrasound bone mineral density (BMD) during pregnancy and postpartum in Korean women. METHODS: We conducted a prospective study between February 2004 and February 2005. Forty-one healthy singleton pregnant women were included. We used quantitative ultrasonography for BMD measurement which is advantageous to pregnant women because it is radiation-free and it provides very accurate BMD that correlates highly with BMD measured by conventional dual energy x-ray absorptiometry. We measured marker of bone resorption (beta-Crosslaps), bone formation [total alkaline phosphatase (ALP), osteocalcin (OC)], total calcium, phosphorus and parathyroid hormone (PTH) during and after pregnancy. RESULTS: During pregnancy, BMD slightly decreased in the third trimester. Bone resorption marker (beta-Crosslaps) increased steadily during pregnancy and immediate postpartum. Markers of bone formation (ALP, osteocalcin) increased from late pregnancy. Total calcium decreased slightly as bone resorption peaks in second trimester. PTH and phosphorus increased steadily throughout pregnancy and postpartum. CONCLUSION: Pregnancy is characterized by high bone turnover in Korean women with resorption preceding formation.
