Assessment of Non-permeability of Gd-DTPA for Dynamic Susceptibility Contrast in Human Brain: A Preliminary Study Using Non-linear Curve Fitting.
- Author:
Seong Ik YOON
1
;
Geon Ho JAHNG
;
Hyun Soo KHANG
;
Young Joo KIM
;
Bo Young CHOE
Author Information
1. Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Korea. bychoe@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Non-linear curve fitting (NLCF);
Dynamic contrast-enhanced (DCE);
Kinetic parameters
- MeSH:
Brain*;
Contrast Media;
Gadolinium DTPA*;
Humans*;
Magnetic Resonance Imaging;
Perfusion
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
2007;11(2):103-109
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To develop an advanced non-linear curve fitting (NLCF) algorithm for performing dynamic susceptibility contrast study of the brain. The first pass effects give rise to spuriously high estimates of Ktrans for the voxels that represent the large vascular components. An explicit threshold value was used to reject voxels. The blood perfusion and volume estimation were accurately evaluated in the T2*-weighted dynamic contrast enhanced (DCE)-MR images. From each of the recalculated parameters, a perfusion weighted image was outlined by using the modified non-linear curve fitting algorithm. The present study demonstrated an improvement of an estimation of the kinetic parameters from the DCE T2*-weighted magnetic resonance imaging data with using contrast agents.
