Update on Genetic Studies of Functional Gastrointestinal Disorders.
10.5223/kjpgn.2010.13.Suppl1.S25
- Author:
Ji Hyun UHM
1
Author Information
1. Department of Pediatrics, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Korea. eomjie@eulji.ac.kr
- Publication Type:Twin Study ; Review
- Keywords:
Irritable bowel syndrome;
Functional dyspepsia;
Candidate genes;
Intermediate phenotypes
- MeSH:
Biology;
Dyspepsia;
Gastrointestinal Diseases;
Genetic Variation;
Humans;
Irritable Bowel Syndrome;
Polymorphism, Genetic
- From:Korean Journal of Pediatric Gastroenterology and Nutrition
2010;13(Suppl 1):S25-S31
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Childhood functional gastrointestinal disorders are defined as a variable combination of often age-dependent, chronic, or recurrent gastrointestinal symptoms not explained by structural or biochemical abnormalities. A better understanding of genetic background of these disorders would help to better identify their complex biology and make it possible to identify subgroups of patients who respond to customized therapies. Family and twin studies have shown a genetic component in irritable bowel syndrome. Candidate gene studies have identified a few genetic polymorphisms that may be associated with functional dyspepsia and irritable bowel syndrome. Studies of associations of spontaneous genetic variations and altered functions may provide novel insights of the mechanisms contributing to the disease.
