An Autopsy Case of Alzheimer's Disease.
- Author:
Taejung KWON
1
;
You Jin WONA
;
Jong Seok LEE
;
Hongil HA
Author Information
1. Division of Forensic Medicine, National Institute of Scientific Investigation, Seoul, Korea. tjkwon@nisi.go.kr
- Publication Type:Case Report
- Keywords:
Alzheimer's disease;
dementia;
pathology
- MeSH:
Aged, 80 and over;
Alzheimer Disease;
Amyloid;
Atrophy;
Autopsy;
Brain;
Cerebral Cortex;
Dementia;
Female;
Hippocampus;
Humans;
Korea;
Neurites;
Neurofibrillary Tangles;
Neurons;
Parietal Lobe;
Plaque, Amyloid
- From:Korean Journal of Legal Medicine
2009;33(1):53-56
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Alzheimer's disease is the leading cause of dementia. We experienced a case of Alzheimer's disease who is 83-year-old woman killed by stab with a knife. She had been suffered from dementia for several years. At autopsy, the brain disclosed cortical atrophy in the frontal, temporal and parietal lobes, and hippocampus. Microscopically, many senile plaques and a few neurofibrillary tangles were observed at the cerebral cortex and hippocampus. Senile plaques were characterized by a spherical structure with or without a dense central core of amyloid, associated with dystrophic neurites. Neurofibrillary tangle was an intracellular filamentous lesion in the cell body of neuron. To our knowledge, this is a rare autopsy case in Korea, therefore, we report here-in and review the clinicopathologic features of Alzheimer's disease.
