A Case of Isoniazid Induced Systemic Lupus Erythematosus.
10.4078/jkra.2007.14.4.431
- Author:
Seong Rheol OH
1
;
Meyoung CHO
;
Han Seung RYU
;
Jae Hun LEE
;
Hae Joong CHO
;
Min Kyu CHOI
;
Jae Min OH
;
Sun Ho AHN
;
Ju Hung SONG
;
Myeung Su LEE
Author Information
1. Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Korea. ckhlms@wonkwang.ac.kr
- Publication Type:Case Report
- Keywords:
Systemic lupus erythematosus;
Isoniazid;
Drug
- MeSH:
Adult;
Anemia;
Antibodies, Antinuclear;
Arthralgia;
Arthritis;
Female;
Fever;
Humans;
Isoniazid*;
Korea;
Lupus Erythematosus, Systemic*;
Pericarditis;
Pleural Effusion;
Pleurisy;
Prednisolone
- From:The Journal of the Korean Rheumatism Association
2007;14(4):431-435
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Many drugs have been known to induce lupus-like syndrome, composing approximately 10% of all SLE cases. Isoniazid-induced lupus erythematosus affects either sex equally and the most common presenting feature is arthralgia or arthritis with anemia. Fever and pleuritis occur in approximately half of the cases, and pericarditis in approximately 30% of cases. We discribe a 28-year-old woman receiving antituberculous medications including isoniazid for one month. She was hospitalized with fever, arthralgia and newly developed pleural effusion The analysis of pleural fluid and serum revealed an elevated level of antinuclear antibody. We suspected of drug induced lupus and stopped isoniazid medication. After discontinuation of isoniazid and short course of prednisolone treatment, her symptoms and pleural effusion disappeared. This case is to our knowledge, the fist report of isoniazid induced SLE in Korea.
