A case of nephrogenic systemic fibrosis following gadolinium exposure in a peritoneal dialysis patient.
- Author:
Tae Hyoung KOO
1
;
Dong Hyun LEE
;
Hee Kyung BAEK
;
Do Kyong KIM
;
Bo Kyung KIM
;
Suk Hee HONG
;
Won Suk AN
Author Information
1. Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. anws@dau.ac.kr
- Publication Type:Case Report
- Keywords:
Nephrogenic systemic fibrosis;
Gadolinium;
Peritoneal dialysis
- MeSH:
Biopsy;
Brain;
Contrast Media;
Extremities;
Fibroblasts;
Gadolinium;
Humans;
Joints;
Korea;
Lower Extremity;
Magnetic Resonance Imaging;
Middle Aged;
Nephrogenic Fibrosing Dermopathy;
Peritoneal Dialysis;
Pliability;
Renal Insufficiency;
Skin
- From:Korean Journal of Medicine
2010;78(4):507-511
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Nephrogenic systemic fibrosis is a systemic illness that only affects patients with kidney failure. Exposure to gadolinium-based contrast agents has been associated with the subsequent development of nephrogenic systemic fibrosis in patients with decreased renal function. Nephrogenic systemic fibrosis is characterized by skin induration after swelling and limited joint movement through a loss in flexibility that preferentially affects the extremities. A 58-year-old man in peritoneal dialysis developed swelling and stiffness of the lower limbs following gadolinium exposure for brain magnetic resonance imaging. This patient was diagnosed with nephrogenic systemic fibrosis by CD34 immunoreactivity of subcutaneous fibroblasts in a skin biopsy. We report, for the first time in Korea, that nephrogenic systemic fibrosis developed after gadolinium exposure in a peritoneal dialysis patient.
