The Role of Prostaglandins in Surgically Induced Miosis.
- Author:
Kyoo Won LEE
1
;
Sung Su LEE
Author Information
1. The First Eye Center, Daegu, Korea.
- Publication Type:Original Article
- Keywords:
Cyclo-oxygenase inhibitor;
Miosis;
Prostaglandins;
Suprofen
- MeSH:
Aqueous Humor;
Cataract;
Constriction;
Humans;
Intraocular Pressure;
Lenses, Intraocular;
Miosis*;
Mydriasis;
Prostaglandin-Endoperoxide Synthases;
Prostaglandins*;
Suprofen
- From:Journal of the Korean Ophthalmological Society
1991;32(11):964-969
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In cataract surgery, the surgically induced miosis complicate the removal of lens materials and implantation of a posterior chamber intraocular lens, which increase the risk of ocular trauma and its associated complication. The refore maintenance of mydriasis during cataract syrgery makes the operation easier and brings a good results. This study was performed in rabbit and human eyes to assess the role of the prostaglandins in surgically induced miosis by observing the reduction of pupillary constriction and by measuring the amount of prostaglandins in aqueous humor when the 1.0% suprofen, cyclo-oxygenase inhibitor, was used, and to assess the effect of suprofen in intraocular pressure. In the results, suprofen inhibits syrgically induced miosis (p value: <0.01, human <0.01) without intraocular pressure change, and for this miosis, prostaglans and for this miosis, prostaglandins are at least partially responsible.
