Single pretreatment of remifentanil may reduce pain after propofol and rocuronium injection in rapid sequence induction.
10.4097/kjae.2012.63.5.413
- Author:
Yoon Ji CHOI
1
;
Han Seok PARK
;
Han LEE
;
Seung Zhoo YOON
Author Information
1. Department of Anesthesiology and Pain Medicine, Asan Medical Center, Seoul, Korea.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Injection pain;
Lidocaine;
Propofol;
Remifentanil;
Rocuronium
- MeSH:
Androstanols;
Anesthesia, General;
Humans;
Incidence;
Lidocaine;
Piperidines;
Propofol;
Tourniquets
- From:Korean Journal of Anesthesiology
2012;63(5):413-418
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We designed this double-blind, placebo-controlled study to compare the efficacy of remifentanil in reducing the pain of both propofol and rocuronium injection during rapid-sequence induction. METHODS: Ninety-five patients, scheduled for elective surgery under general anesthesia, were divided into 3 groups: saline (Group S, n = 31), remifentanil 1 microg/kg (Group R, n = 32), and lidocaine 1.5 mg/kg (Group L, n = 32) were administered after tourniquet application. The occlusion was released after 1 min and 5 ml of 1% propofol was injected over 10 s. Pain on propofol injection was evaluated by a 10-point verbal numeric rating scale (VNRS). The rest of the induction dose of propofol and 1 mg/kg of rocuronium, were injected. Pain on rocuronium injection was evaluated by a four-point score (FPS). RESULTS: The VNRS of propofol injection was as follows: R (0.78) = L (1.34) < S (4.26). The incidence of withdrawal response due to rocuronium was as follows: R (6.3%) < L (53.1%) < S (83.9%). The FPS of rocuronium injection was as follows: R (0.81) < L (1.78) < S (2.93). CONCLUSIONS: Pretreatment with a bolus of remifentanil was effective in simultaneously reducing injection pain of propofol and rocuronium. In addition, remifentanil pretreatment was more effective in suppression of withdrawal response by rocuronium than lidocaine.
