Renal Insufficiency Secondary to Leukemic Infiltration in Chronic Lymphocytic Leukemia: A Case Report.
- Author:
Jin Suk KIM
1
;
Hyung Yoon KIM
;
Han Sang LEE
;
Hae Ran LEE
;
Han Seong KIM
;
Ji Yeon PARK
;
Seong Yoon YI
Author Information
1. Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea. Dr-Yi@paik.ac.kr
- Publication Type:Case Report
- Keywords:
Chronic lymphocytic leukemia;
Leukemic infiltration;
Renal insufficiency;
Proteinuria
- MeSH:
Adult;
Biopsy;
Cyclophosphamide;
Diagnosis, Differential;
Humans;
Leukemia, Lymphocytic, Chronic, B-Cell;
Leukemic Infiltration;
Proteinuria;
Renal Insufficiency;
Vidarabine
- From:Korean Journal of Medicine
2012;83(1):132-135
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Renal infiltration is common in chronic lymphocytic leukemia (CLL), but renal impairment caused by leukemic infiltration is rare. This report describes the case of a 38-year-old man with CLL who required no medical treatment for 1 year and was admitted with nonoliguric renal insufficiency (proteinuria > 2,000 mg/day). A renal biopsy subsequently revealed leukemic infiltration by CLL. Treatment with fludarabine plus cyclophosphamide resulted in the improvement of renal function. Leukemic infiltration should be considered in the differential diagnosis of a patient with CLL and impaired renal function because renal impairment often responds well to chemotherapy.
