The Effects of Family History of Colorectal Cancer on the Development of Colorectal Adenoma.
- Author:
Min Young CHOI
1
;
Byeong Gwan KIM
;
Ji Won KIM
;
Kook Lae LEE
;
Ji Bong JEONG
;
Jae Kyung LEE
;
Yong Jin JUNG
;
Won KIM
;
Dong Won AHN
;
Young Hoon KIM
;
Sae Kyung JOO
;
Mee Soo CHANG
;
Hyeoung Ju KWON
Author Information
- Publication Type:Original Article ; English Abstract
- Keywords: Colorectal neoplasms; Colorectal adenoma; Family history of colorectal cancer; Bcl-2-associated X protein
- MeSH: Adenoma/*diagnosis/epidemiology/metabolism; Adult; Age Factors; Aged; Colonoscopy; Colorectal Neoplasms/*diagnosis/epidemiology/metabolism; *Family Health; Female; Humans; Immunohistochemistry; Incidence; Male; Middle Aged; Proto-Oncogene Proteins c-akt/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Retrospective Studies; Risk Factors; Transcription Factor RelA/metabolism; bcl-2-Associated X Protein/metabolism; beta Catenin/metabolism
- From:The Korean Journal of Gastroenterology 2012;60(1):36-41
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND/AIMS: Early detection of polyp is important for the prevention of colorectal cancer (CRC). There have been few studies to investigate the relationship between colorectal adenoma and family history of CRC (FHCRC) in Korea. The aim of this study was to identify the relationship between colorectal adenoma and FHCRC. METHODS: Between March 2009 and September 2010, 225 patients with adenomatous polyps were included. Their medical records with clinical history and size, numbers, histology of polyps were reviewed. Immunohistochemical staining using Bcl-2, Bax, p-AKT, NF-kappaB, and beta-catenin antibodies were performed. We compared the histology of adenoma and expression of immunohistochemical staining according to the existence of FHCRC. RESULTS: The incidence of colorectal adenoma increased in case of FHCRC (p=0.029). In patients with FHCRC, the mean age of patients was 49 years old and younger than patients without FHCRC. In addition in patients with FHCRC, the incidence of advanced adenoma was significantly higher than in patients without FHCRC (p=0.001). The expression of Bax was significantly lower in patients with FHCRC than without FHCRC (p=0.046). CONCLUSIONS: There was a tendency for polyp to develop in their younger ages and to be more advanced adenomas in patients with FHCRC. The low expression of Bax, tumor suppressor gene, might be associated with the development of polyps in patient with FHCRC. Therefore, patients with FHCRC may be better to start screening colonoscopy earlier than patient without FHCRC.
