Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study.
10.4082/kjfm.2012.33.4.190
- Author:
Byoung Jin PARK
1
;
Yong Jae LEE
;
Hye Ree LEE
;
Dong Hyuk JUNG
;
Ha Young NA
;
Hong Bae KIM
;
Jae Yong SHIM
Author Information
1. Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea. hope@yuhs.ac
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Panax ginseng;
Metabolic Syndrome;
Randomized Controlled Trial
- MeSH:
Administration, Oral;
Blood Glucose;
Blood Pressure;
Fasting;
Lipoproteins;
Lipoproteins, LDL;
Panax;
Pulse Wave Analysis;
Vascular Stiffness
- From:Korean Journal of Family Medicine
2012;33(4):190-196
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study investigated the effects of Korean red ginseng (KRG) supplementation on metabolic parameters, inflammatory markers, and arterial stiffness in subjects with metabolic syndrome. METHODS: We performed a randomized, double-blind, placebo-controlled, single-center study in 60 subjects who were not taking drugs that could affect metabolic and vascular functions. Subjects were randomized into either a KRG (4.5 g/d) group or a placebo group for a 12-week study. We collected anthropometric measurements, blood for laboratory testing, and brachial-ankle pulse wave velocity (baPWV) at the initial (week 0) and final (week 12) visits. RESULTS: A total of 48 subjects successfully completed the study protocol. Oral administration of KRG did not significantly affect blood pressure, oxidative or inflammatory markers, or baPWV. CONCLUSION: We found no evidence that KRG had an effect on blood pressure, lipid profile, oxidized low density lipoprotein, fasting blood glucose, or arterial stiffness in subjects with metabolic syndrome. These findings warrant subsequent longer-term prospective clinical investigations with a larger population. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT00976274
