Study of Empirical Antifungal Therapy in Febrile Neutropenia and Invasive Fungal Infection after Introduction of Novel Antifungal Agents.
- Author:
Eun Jung LEE
1
;
Tae Hyong KIM
;
Eun Ju CHOO
;
Min Hyok JEON
Author Information
1. Department of Internal Medicine, College of Medicine, SoonChunHyang University, Seoul, Korea. geuncom@hosp.sch.ac.kr
- Publication Type:Original Article
- Keywords:
Empirical antifungal therapy;
Febrile neutropenia
- MeSH:
Anti-Bacterial Agents;
Antifungal Agents;
Humans;
Leukemia;
Lymphoma;
Medical Records;
Neutropenia;
Retrospective Studies
- From:Korean Journal of Medical Mycology
2009;14(4):177-181
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Patients with prolonged empirical broad spectrum antibiotics for febrile neutropenia (FN) with cancer, inevitably have increased risk of invasive fungal infections owing to the altered endogenous microbial environment. OBJECTIVE: The purpose of this study is to evaluate the impact of empirical antifungal therapy on occurrence of invasive fungal infections (IFIs) during FN with cancer. METHODS: We retrospectively reviewed medical records of patients with FN after cytotoxic chemotherapy due to cancer from July, 2003 to June, 2007. RESULTS: We identified 91 patients with FN after cytotoxic chemotherapy. Most common underlying conditions were lymphoma (20/91, 22%) and leukemia (20/91, 22%). IFIs occurred in 10% (9/91). In a comparison of patients with empirical antifungal therapy with no antifungal therapy, the duration of neutropenia was significantly increased with IFIs (p=0.09). The mortality of IFIs was 55.5% (5/9). CONCLUSION: We found that the duration of FN than empirical antifungal therapy affected occurrence of IFIs.
