Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease.
- Author:
Dong Hyun CHOI
1
;
Seong Ho KANG
;
Heesang SONG
Author Information
- Publication Type:Review
- Keywords: Mean platelet volume; Atrial fibrillation; Ischemic stroke; Coronary artery disease; Percutaneous coronary intervention
- MeSH: Atherosclerosis; Atrial Fibrillation; Blood Cell Count; Blood Platelets; Coronary Artery Disease; Heart Diseases*; Heart*; Humans; Inflammation; Mean Platelet Volume*; Percutaneous Coronary Intervention; Prescriptions; Prognosis*; Stroke; Thrombosis
- From:The Korean Journal of Internal Medicine 2016;31(6):1009-1017
- CountryRepublic of Korea
- Language:English
- Abstract: Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombosis. They secrete and express many substances that are crucial mediators of coagulation, inflammation, and atherosclerosis. Mean platelet volume (MPV) is a precise measure of platelet size, and is routinely reported during complete blood count analysis. Emerging evidence supports the use of MPV as a biomarker predicting the risk of ischemic stroke in patients with atrial fibrillation, and as a guide for prescription of anticoagulation and rhythm-control therapy. In addition, MPV may predict the clinical outcome of percutaneous coronary intervention (PCI) in patients with coronary artery disease and indicate whether additional adjunctive therapy is needed to improve clinical outcomes. This review focuses on the current evidence that MPV may be a biomarker of the risk and prognosis of common heart diseases, particularly atrial fibrillation and coronary artery disease treated via PCI.
