Vitamin D and its effects on cardiovascular diseases: a comprehensive review.
- Author:
Nonanzit PÉREZ-HERNÁNDEZ
1
;
Gad APTILON-DUQUE
;
María Cristina NOSTROZA-HERNÁNDEZ
;
Gilberto VARGAS-ALARCÓN
;
José Manuel RODRÍGUEZ-PÉREZ
;
Ruben BLACHMAN-BRAUN
Author Information
- Publication Type:Review
- Keywords: Vitamin D; Cardiovascular system; Metabolic networks and pathways
- MeSH: Animals; Atrial Fibrillation; Blood Pressure; Calcium; Cardiovascular Diseases*; Cardiovascular System; Coronary Artery Disease; Heart Failure; Humans; Immune System; Metabolic Networks and Pathways; Metabolism; Molecular Biology; Public Health; Renin-Angiotensin System; Vascular Diseases; Vitamin D*; Vitamins*
- From:The Korean Journal of Internal Medicine 2016;31(6):1018-1029
- CountryRepublic of Korea
- Language:English
- Abstract: Vitamin D is a molecule that is actively involved in multiple metabolic pathways. It is mostly known for its implications related to calcium metabolism. It has also been determined that it actively participates in the cardiovascular system, influencing blood pressure, coronary artery disease and other vascular diseases, such as heart failure and atrial fibrillation. Furthermore, it has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system. In this review, we present the different vitamin D metabolic pathways associated with the cardiovascular pathophysiology, and we include studies in animal and human models, as well as some of the controversies found in the literature. This review also incorporates an overview of the implications in the molecular biology and public health fields.
