Glomerular filtration rate affects interpretation of pulmonary function test in a Korean general population: results from the Korea National Health and Nutrition Examination Survey 2010 to 2012.
- Author:
Young Soo KIM
1
;
Hee Yeon KIM
;
Hyo Suk AHN
;
Tae Seo SOHN
;
Jae Yen SONG
;
Young Bok LEE
;
Dong Hee LEE
;
Jae Im LEE
;
Tae Kyu LEE
;
Seong Cheol JEONG
;
Mihee HONG
;
Hiun Suk CHAE
;
Kyungdo HAN
;
Chang Dong YEO
Author Information
- Publication Type:Original Article
- Keywords: Respiratory function tests; Glomerular filtration rate
- MeSH: Accidental Falls; Cross-Sectional Studies; Female; Forced Expiratory Volume; Glomerular Filtration Rate*; Humans; Kidney Failure, Chronic; Korea*; Linear Models; Male; Nutrition Surveys*; Prevalence; Respiratory Function Tests*; Transplant Recipients; Vital Capacity
- From:The Korean Journal of Internal Medicine 2016;31(6):1101-1109
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The pulmonary abnormalities (principally restrictive abnormalities) are characteristic of renal transplant recipients or those with end-stage renal disease. Our aim was to explore whether the prevalence of spirometric abnormalities was influenced by the estimated glomerular filtration rates (GFRs) in a Korean general population. METHODS: We used data obtained during the 2010 to 2012 Korean National Health and Nutrition Examination Survey, a national cross-sectional survey. We analyzed data from subjects for whom spirometric assays and estimated GFRs were of acceptable quality. RESULTS: A total of 8,809 subjects (3,868 male and 4,941 female) was included. In both males and females with GFR values < 60 mL/min/1.73 m², the linear trends toward the presence of obstructive and restrictive patterns were significant. However, the percent predicted forced vital capacity (FVC) decreased with a decline in the estimated GFR, but only in males (p for trend < 0.0031). Multivariate linear regression analysis showed a decline in the estimated GFR was independently associated with falls in the percent predicted FVC and the forced expiratory volume in 1 second/FVC ratio in both males and females. However, the percent predicted FVC was independently predictive only in males (p = 0.002). CONCLUSIONS: Impaired pulmonary function was associated with a decline in the estimated GFR. The percent predicted FVC decrease paralleled the decline in estimated GFR in male only. Careful interpretation of pulmonary function test data is required in patients with decreased GFRs or impaired renal function, especially males.
