Mapping of the Faded (fe) Gene to a Region between D10mit191 and D10mit44 on Mouse Chromosome 10.
- Author:
Seung Hun OH
1
;
Yoonyi NAM
;
Jun Gyo SUH
Author Information
- Publication Type:Original Article
- Keywords: Genetic mapping; linkage analysis; faded gene; chromosome 10
- MeSH: Animals; Chromosomes, Human, Pair 10; Gene Order; Genes, Recessive; Humans; Mice; Mice, Inbred CBA; Penetrance; Pigmentation
- From:Laboratory Animal Research 2011;27(1):41-46
- CountryRepublic of Korea
- Language:English
- Abstract: The faded mouse is a coat color mutant that shows faded coat color and age-related loss of pigmentation. This mutation is transmitted by an autosomal recessive gene with 100% penetrance. In the present study, we carried out linkage analysis of the faded (fe) gene using intra-specific backcross panels. Affected faded mice were carefully confirmed by their faded coat color at about 4 weeks of age. In the intra-specific backcross between faded and CBA mice (n=198), the fe gene was mapped to a region 2.1 cM distal to D10mit191. Therefore, the gene order was defined as follows: centromere-D10mit51 (12.4+/-2.4 cM)-D10mit191 (2.1+/-1.0 cM)-fe-D10mit44 (13.3+/-2.4 cM)-D10mit42 (14.4+/-2.5 cM). This linkage map of the fe locus will provide a good entry point to isolate the fe gene. Since the faded mouse has pigmentary abnormalities, this mutant may be a useful model for studies of pigmentary abnormalities in humans.
