What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?.
10.4111/kju.2014.55.11.725
- Author:
Renato Caretta CHAMBO
1
;
Fabio Hissachi TSUJI
;
Flavio DE OLIVEIRA LIMA
;
Hamilto Akihissa YAMAMOTO
;
Carlos Marcio Nobrega DE JESUS
Author Information
1. Graduate in Base of Surgery Program, Botucatu Medical School, Sao Paulo State University, Botucatu, Sao Paulo, Brazil. renato.chambo@gmail.com
- Publication Type:Original Article ; Controlled Clinical Trial
- Keywords:
Needle biopsy;
Prostate;
Prostatic neoplasms
- MeSH:
Adult;
Aged;
Cell Proliferation;
Endosonography/*methods;
Equipment Design;
Follow-Up Studies;
Humans;
Image-Guided Biopsy/*instrumentation;
Male;
Middle Aged;
Neoplasm Grading;
Neoplasm Staging;
Prospective Studies;
Prostate/metabolism/pathology;
Prostate-Specific Antigen/metabolism;
Prostatic Intraepithelial Neoplasia/metabolism/*pathology;
Prostatic Neoplasms/metabolism/*pathology;
Rectum;
Reproducibility of Results
- From:Korean Journal of Urology
2014;55(11):725-731
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We evaluated the utility of 10-, 12-, and 16-core prostate biopsies for detecting prostate cancer (PCa) and correlated the results with prostate-specific antigen (PSA) levels, prostate volumes, Gleason scores, and detection rates of high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP). MATERIALS AND METHODS: A prospective controlled study was conducted in 354 consecutive patients with various indications for prostate biopsy. Sixteen-core biopsy specimens were obtained from 351 patients. The first 10-core biopsy specimens were obtained bilaterally from the base, middle third, apex, medial, and latero-lateral regions. Afterward, six additional punctures were performed bilaterally in the areas more lateral to the base, middle third, and apex regions, yielding a total of 16-core biopsy specimens. The detection rate of carcinoma in the initial 10-core specimens was compared with that in the 12- and 16-core specimens. RESULTS: No significant differences in the cancer detection rate were found between the three biopsy protocols. PCa was found in 102 patients (29.06%) using the 10-core protocol, in 99 patients (28.21%) using the 12-core protocol, and in 107 patients (30.48%) using the 16-core protocol (p=0.798). The 10-, 12-, and 16-core protocols were compared with stratified PSA levels, stratified prostate volumes, Gleason scores, and detection rates of HGPIN and ASAP; no significant differences were found. CONCLUSIONS: Cancer positivity with the 10-core protocol was not significantly different from that with the 12- and 16-core protocols, which indicates that the 10-core protocol is acceptable for performing a first biopsy.
