The Change of Platelet Count and Plasma Fibrinogen Level during and after Extracorporeal Circulation .
10.4097/kjae.1988.21.5.764
- Author:
Mun Han YOON
1
;
Heung Dae KIM
Author Information
1. Department of Anesthesiology, College of Medicine, Yeungnam University, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Open heart surgery;
Extracorporeal circulation;
Platelet;
Fibrinogen
- MeSH:
Blood Platelets*;
Extracorporeal Circulation*;
Fibrinogen*;
Hemorrhage;
Humans;
Oxygen;
Oxygenators;
Oxygenators, Membrane;
Plasma*;
Platelet Count*;
Thoracic Surgery
- From:Korean Journal of Anesthesiology
1988;21(5):764-771
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In order to evaluate causes and the effective treatment of postoperative bleeding after open heart surgery, we measured platelet count and plasma fibrinogen levels before, during a 30 and 60-minute, and after a 30, 60 and 90-minute extracorporeal circulation in 5 patients perfused by a bubble and membrane oxygenator, respectively. The results were as follows: 1) The platelet count was reduced significantly by 57.2+/-3.04% during a 30-minute extracorporeal circulation using the bubble oxygenator and by 43.8+/-0.84% using the membrane oxygenator, and these levels were maintained throughout the extracorporeal circulation. 2) The platelet count after a 90-minute extracorporeal circulation increased significantly compared with after a 30-minute extracorporeal circulation (p<0.05) and these effects were more prominent using the bubble oxygenator (p<0.025). 3) The plasma fibrinogen level was reduced by 28.6+/-7.50% during a 30-minute extracorporeal circulation using the bubble oxygenator and by 33.6+/-5.77% using the membrane oxygenator, and these levels were maintained throughout the extracorporeal circulation. 4) The plasma fibrinogen level after a 90-minute extracorporeal circulation increased significantly compared with after a 30-minute extracorporeal circulation (p<0.05).
